Studies on SF=1902 A2 A5, minor components of SF-1902 (globomycin).

Isolation and structure of SF-1902 A5, a new globomycin analogue.

SF-1902 is a solvent-soluble, neutral antibiotic produced by Streptomyces hygroscopicus SF-19021). It shows antibacterial activity only against Gram-negative bacteria2). HPLC analysis of the sample seemingly homogeneous on TLC (silica gel, chloroform methanol, 5: 1, or acetone benzene, 2: 1) disclosed the presence of several minor components and one major component SF-1902, as shown in Fig. 1. ...

CD95-Mediated control of anti-citrullinated protein/peptides antibodies (ACPA)-producing plasma cells occurring in rheumatoid arthritis inflamed joints.

OBJECTIVE Serum anti-citrullinated protein/peptides antibodies (ACPA) are a valuable diagnostic parameter that might be involved in rheumatoid arthritis (RA) pathogenesis. CD95-dependent apoptosis is defective in RA synovium. The present study explores the occurrence of ACPA IgG, and the CD95-mediated control of ACPA IgG-secreting plasma cells (PC) in RA patients. METHODS Mononuclear cells (M...

Importance of assessing all components of the metabolic syndrome in adolescents.

Prediction of accurate pKa values of some α-substituted carboxylic acids with low cost of computational methods

The acidity constants (pKa) of thirty four (34) ;-substituted carboxylic acids in aqueous solution havebeen calculated using conductor-like polarizable continuum (C-PCM) solvation model. The gasphaseenergies at the Density Functional Theory (DFT-MPW1PW91) and solvation energies atHartree Fock (HF) are combined to estimate the pKa values which are very close to the experimentalvalues where, and ...

Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes.

The isothiocyanate sulforaphane (SF) is thought to be a potential chemoprotective agent. Its effects on Phase I and Phase II enzymes of carcinogen metabolism in primary cultures of rat and human hepatocytes have been investigated. Northern blot analyses of rat hepatocytes showed a dose-dependent induction of mRNAs for rat glutathione S-transferases (rGSTs) A1/A2 and P1 but not M1. This was asso...